Potencial evocado cognitivo P300 em crianças: valores de referência
Event-related evoked potential P300 in children: reference values
Aline Pinto Kropidlofscky; Camila Goldstein Fridman; Viviann Magalhães Silva Borges; Dayane Domeneghini Didoné; Paulo Ricardo Gazzola Zen; Pricila Sleifer
Resumo
Palavras-chave
Abstract
Purpose:To measure and compare P300 latency and amplitude in normal hearing children at different age groups.
Methods: A cross-sectional study with 96 children aged between 8 and 11 years and 11 months, equally divided into four age-based groups. P300 assessment was conducted using the Masbe ATC Plus equipment (Contronic®), with 1000 Hz and 2000 Hz stimuli, at an 80/20% probability.
Results: The mean P300 latency and amplitude values were 339.57 ± 41.03 and 18.22 ± 7.59 in G1, 327.94 ± 37.29 and 16.32 ± 7.01 in G2, 321.05 ± 31.84 and 15.86 ± 5.08 in G3, and 310.76 ± 28.99 and 11.24 ± 3.12 in G4, respectively.
Conclusion: All children presented P300. There were no differences regarding P300 latencies and amplitudes when comparing different age groups in this study.
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References
1 ASHA: American Speech-Language Hearing Association. (Central) auditory processing disorders—the role of the audiologist [Internet]. Rockville: ASHA [citado em 2020 Out 1]. Disponível em:
2 Souza LCA, Piza MRT, Alvarenga KF, Cóser PL. Potenciais Evocados Auditivos Corticais Relacionados a Eventos (P300). In: Souza LCA, Piza MRT, Alvarenga KF, Cóser PL. Eletrofisiologia da audição e emissões otoacústicas: Princípios e aplicações clínicas. 2. ed. Ribeirão Preto: Editora Novo Conceito; 2010. p. 95-107.
3 Sanfins MD, Matas CG. Potencial Evocado Auditivo de Longa Latência (PEALL): Potencial Cognitivo (P300). In: Menezes PL, Sanfins MD, Capra D, Andrade KCL, Frizzo ACF. Manual de Eletrofisiologia e Eletroacústica: um guia para clínicos. Ribeirão Preto: BookToy, 2022. p. 251-64.
4 Didoné DD. Potencial Evocado Auditivo Cortical em nascidos a termo e pré-termo [tese]. Porto Alegre: Faculdade de Medicina, Universidade Federal do Rio Grande do Sul; 2018.
5 Polich J, Howard L, Starr A. Effects of age on the P300 component of the event-related potential from auditory stimuli: peak definition, variation, and measurement. J Gerontol. 1985;40(6):721-6.
6 Barajas JJ. The effects of age on human P3 latency. Acta Otolaryngol Suppl. 1990;476:157-60.
7 McPherson DL. Late potentials of the auditory system. San Diego: Singular Pub. Group; 1996.
8 Duarte JL, Alvarenga KF, Banhara MR, de Melo ADP, Sás RM, Costa AO Fo. Potencial evocado auditivo de longa latência-P300 em indivíduos normais: valor do registro simultâneo em Fz e Cz. Rev Bras Otorrinolaringol. 2009;75(2):231-6.
9 Souza J, Rocha VO, Berticelli AZ, Didoné DD, Sleifer P. Potencial Evocado Auditivo de Longa Latência – P3 em crianças com e sem queixas de dificuldade de aprendizagem. Audiol Commun Res. 2017;22:e1690.
10 Seçen Yazıcı M, Serdengeçti N, Dikmen M, Koyuncu Z, Sandıkçı B, Arslan B, et al. Evaluation of p300 and spectral resolution in children with attention deficit hyperactivity disorder and specific learning disorder. Psychiatry Res Neuroimaging. 2023;334:111688.
11 Vaney N, Khaliq F, Anjana Y. Event-related potentials study in children with borderline intellectual functioning. Indian J Psychol Med. 2015;37(1):53-7.
12 Kamita MK, Silva LAF, Matas CG. Potenciais evocados auditivos corticais no transtorno do espectro do autismo: revisão sistemática. CoDAS. 2021;33(2):e20190207.
13 Foo HC, Tang C, Kao Y, Wu H, Chang C, Wu M, et al. The latency of auditory event-related potential P300 prolonged in school-age students with unilateral hearing loss in a mandarin learning environment. Am Ann Deaf. 2024;168(5):241-57.
14 Hussain RO, Kumar P, Singh NK. Subcortical and cortical electrophysiological measures in children with speech-in-noise deficits associated with auditory processing disorders. J Speech Lang Hear Res. 2022;65(11):4454-68.
15 Advíncula KP, Griz SMS, Frizzo ACF, Pessoa ACRG, Leite-Barros PMA, Gurgel E. Potenciais evocados auditivos de longa latência em crianças com desvio fonológico. Distúrb Comun. [Internet]. 2008 [citado em 2020 Out 1]. 20(2):171-81. Disponível em:
16 Leite RA, Wertzner HF, Matas CG. Potenciais evocados auditivos de longa latência em crianças com transtorno fonológico. Pró-Fono R Atual Cient. 2010;22(4):561-6.
17 Regaçone SF, Gução ACB, Giacheti CM, Romero ACL, Frizzo ACF. Potenciais evocados auditivos de longa latência em escolares com transtornos específicos de aprendizagem. Audiol Commun Res. 2014;19(1):13-8.
18 Fuchigami T, Okubo O, Ejiri K, Fujita Y, Kohira R, Noguchi Y, et al. Developmental changes in P300 wave elicited during two different experimental conditions. Pediatr Neurol. 1995;13(1):25-8.
19 van Dinteren R, Arns M, Jongsma ML, Kessels RP. P300 development across the lifespan: a systematic review and meta-analysis. PLoS One. 2014;9(2):e87347.
20 Northern JL, Downs MP. O sistema auditivo. In: Northern JL, Downs MP. Audição na infância. 5. ed. Rio de Janeiro: Guanabara Koogan; 2005. p. 29-46.
21 Jerger J. Clinical experience with impedance audiometry. Arch Otolaryngol. 1970;92(4):311-24.
22 Matas CG, Magliaro FCL. Potencial evocado auditivo de tronco encefálico. In: Boéchat EM, Menezes PL, Couto CM, Frizzo ACF, Scharlach RC, Anastasio ART. Tratado de audiologia. 2. ed. Rio de Janeiro: Guanabara Koogan; 2015. p. 118-25.
23 Didoné DD, Garcia MV, Oppitz SJ, Silva TF, Santos SN, Bruno RS, et al. Auditory evoked potential P300 in adults: reference values. Einstein (Sao Paulo). 2016;14(2):208-12.
24 Landis JR, Koch GG. The measurement of observer agreement for categorical data. Biometrics. 1977;33(1):159-74.
25 Fleiss JL. The design and analysis of clinical experiments. New York: John Wiley & Sons; 1986.
26 Vannasing P, Dionne-Dostie E, Tremblay J, Paquette N, Collignon O, Gallagher A. Electrophysiological responses of audiovisual integration from infancy to adulthood. Brain Cogn. 2024;178:106180.
27 Santopetro NJ, Brush CJ, Mulligan EM, Hajcak G. Influences of age and pubertal development on P300 amplitude trajectory across two years in female adolescents. Dev Cogn Neurosci. 2023;60:101212.
28 Melynyte S, Wang GY, Griskova-Bulanova I. Gender effects on auditory P300: a systematic review. Int J Psychophysiol. 2018;133:55-65.
29 Reis ACMB, Frizzo ACF. Potencial evocado auditivo cognitivo. In: Boéchat EM, Menezes PL, Couto CM, Frizz ACF, Scharlach RC, Anastasio ART. Tratado de audiologia. 2. ed. Rio de Janeiro: Guanabara Koogan; 2015. p. 140-50.
Submitted date:
05/18/2025
Accepted date:
09/20/2025
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